ProteinLens — Binding Site Explorer

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AlphaFold avg pLDDT

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Data provenance

UniProt annotations

Sequence, natural variants, disease comments, GO terms, and annotated residues come directly from the UniProt entry.

Data provenance

AlphaFold confidence

Average confidence and confidence bins are calculated from per-residue pLDDT values parsed from the AlphaFold mmCIF model when available.

Interpretation

Inferred summaries

Priority labels and short notes are interface-level summaries. They are not new experimental predictions.

⚠ Disease Association Pathogenic variants reported

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Canonical Sequence

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Annotated Functional / Binding Residues

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Structure Confidence (pLDDT)

Very High (≥90)—

Confident (70–89)—

Low (50–69)—

Very Low (<50)—

Reliable

Good

Flexible

Disordered

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🧊 3D Structure — AlphaFold Model

3D interactive structure available at AlphaFold Database

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Molecular Function

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Biological Process

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Disease-Associated Variants

Source: UniProt Natural Variants

Position	Change	Pathogenicity	Associated Disease / Note
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